Hot Topic Day “Colon targeting”

Lille, France, 29th November 2022

The Interreg 2 Seas project “Site Drug: Specifc Drug Delivery” and the APGI are jointly organizing a “Hot Topic Day” dedicated to a highly challenging field of research and development: Local Controlled Drug Delivery.

The large majority of drug products available on the market deliver the drug in a non-targeted manner into the human body: The drug is circulated via the blood throughout the entire organism.

Parts of it reach the target site (e.g., a specific organ). However, the large majority of the administered drug dose is distributed within the rest of the body. Importantly, this drug is not only “lost” for the treatment, it is often harmful for the patient, causing potentially severe side effects.

The latter have 3 major consequences, they:

  • constitute a major health burden for the patient (e.g. causing nausea, headache, cardiovascular complications)
  • can limit the drug dose that can be given to the patient, leading to non-optimal therapeutic effects (the drug amount reaching the target site cannot be further increased)
  • cause considerable costs for the health care systems (e.g. due to the treatment of side effects, prolonged).

The Hot Topic Day will be held in-person to allow for intensive exchanges. The scientific programme is as follows:

9:00-9:10 Welcome

Parenteral Local Controlled Drug Delivery

A new understanding of drug release from PLGA-based drug delivery systems
Prof. Juergen Siepmann, University of Lille, France

Local periodontitis treatments: Formulation strategies and clinical aspects
Prof. Florence Siepmann and Dr. Kevimy Agossa, University of Lille, France

10:20-10:50 Coffee break

Oral Local Controlled Drug Delivery

Colon Targeting: Opportunities and pitfalls
Prof. Abdul Basit, University College London, UK

Advanced in vitro drug release testing along the gastrointestinal tract
Prof. Tom Van de Wiele, ProDigest, Belgium

12:00-13:30 Lunch break

Advanced Characterization Methods: In vitro and in vivo

Cutting edge characterization for local drug delivery systems
Prof. Axel Zeitler, University of Cambridge, UK

Zebra fish: An interesting in vivo model for drug product development
Prof. Jeroen Bussmann, University of Leiden, The Netherlands

14:40-15:10 Coffee break

Manufacturing of Local Drug Delivery Systems

The potential of 3D Printing for local controlled drug delivery
Dr. Atheer Awad, University College London,UK

An Engineering perspective on 3D printing of local drug delivery systems
Dr. Julian Apachitei, University of Delft, The Netherlands

Toward continuous manufacturing of local drug delivery systems
Prof. Chris Vervaet, University of Ghent, Belgium

16:55-17:00 Closing

Gare St-Sauveur, 17 Boulevard Jean-Baptiste Lebas,  Lille. Subway : line 2, station “Mairie de Lille” or “Lille Grand Palais”
Lille can be easily reached by train (TGV  and Eurostar: 30 min from Brussels, 50 min from Paris, 1.30 h from London), by plane (Lille Lesquin Airport, or Paris Charles de Gaulle Airport & 50 min by train, or Brussels International Airport & 2 x 30 min by train), as well as by car.

For more information: